3-Amino-2-pyridinecarboxylic acid
2-Pyridinecarboxylic acid, 3-amino-
CAS: 1462-86-8
Molecular Formula: C6H6N2O2
3-Amino-2-pyridinecarboxylic acid - Names and Identifiers
| Name | 2-Pyridinecarboxylic acid, 3-amino- |
| Synonyms | AKOS 92172 H-3APC2-OH IFLAB-BB F2113-0045 RARECHEM AQ NN 0176 3-AMINOPICOLINIC ACID 3-Aminopicolinic Acid 3-Amino-2-carboxypyridine 3-aminopyridine-2-carboxylate 3-amino-2-pyridinecarboxylicaci 3-aminopyridine-2-carboxylic acid 3-Amino-2-pyridinecarboxylic acid 3-AMINO-2-PYRIDINECARBOXYLIC ACID 3-AMINO-PYRIDINE-2-CARBOXYLIC ACID 2-Pyridinecarboxylic acid, 3-amino- |
| CAS | 1462-86-8 |
| EINECS | 215-971-8 |
| InChI | InChI=1/C6H6N2O2/c7-4-2-1-3-8-5(4)6(9)10/h1-3H,7H2,(H,9,10)/p-1 |
3-Amino-2-pyridinecarboxylic acid - Physico-chemical Properties
| Molecular Formula | C6H6N2O2 |
| Molar Mass | 138.12 |
| Density | 1.417±0.06 g/cm3(Predicted) |
| Melting Point | 218-220 |
| Boling Point | 386.6±27.0 °C(Predicted) |
| Flash Point | 187.6°C |
| Solubility | Soluble in acetone, ethanol and methanol. |
| Vapor Presure | 1.14E-06mmHg at 25°C |
| Appearance | Green or brown crystals |
| Color | Yellow to pale brown |
| pKa | 1.32±0.50(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| MDL | MFCD00090153 |
3-Amino-2-pyridinecarboxylic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves. S60 - This material and its container must be disposed of as hazardous waste. |
| RTECS | US5175000 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
3-Amino-2-pyridinecarboxylic acid - Reference Information
| properties | 3-aminopyridine -2-carboxylic acid (3-Amino-2-pyridinecarboxylic acid), also known as 3-amino -2-carboxylic acid pyridine, 3-amino -2-pyridine carboxylic acid, its molecular formula is C6H6N2O2, molecular weight is 138.12,CAS number is 1462-86-8, its solid at room temperature, melting point 218-220 ℃, soluble in acetone, ethanol and methanol. |
| Uses | 3-aminopyridine-2-carboxylic acid is used to prepare piperidinylmethylpurine as NSD2 inhibitor and anti-cancer drug. |
| Application example | 3-aminopyridine-2-carboxylic acid is mainly used in pharmaceutical synthesis. (1) Synthesis of 3-mercaptopyridine 2-formic acid: Studies have found that compounds containing n-pyridine carboxylic acid structure have a good inhibitory effect on gluconeogenesis, among which 3-mercaptopyridine 2-formic acid (4) is a good Reagents for lowering blood sugar;(2) Synthesis of fused ring 4-oxo-pyrimidine derivatives: nippon Wanyou Pharmaceutical Co., Ltd. used 3-aminopyridine-2-carboxylic acid, acetic anhydride and 4-(3-piperidine-1-ylpropoxy) aniline · mono-( toluenesulfonic acid) salt as raw materials to synthesize fused ring 4-oxo-pyrimidine derivatives. Specific fused-ring 4-oxo-pyrimidine derivatives can be used as histamine H3 receptor antagonists or inverse agonists. Histamine H3 receptors exist in the presynaptic membranes of central or peripheral nerve cells and act as autoreceptors to control the release of histamine and also control the release of other neurotransmitters. |
Last Update：2024-04-09 15:16:47
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